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Highly Efficient 4-O-Alkylations of Tetronic Acids Involving Oxyphosphonium Intermediates.

✍ Scribed by Franz F. Paintner; Lars Allmendinger; Gerd Bauschke


Book ID
101939369
Publisher
John Wiley and Sons
Year
2003
Weight
138 KB
Volume
34
Category
Article
ISSN
0931-7597

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A novel, highly efficient and racemization free coupling procedure for sterically hindered N-alkyl amino acids has been developed using triphosgene and a combination of diisopropylethyl amine (DIEA) and collidine at room temperature. Its efficiency was demonstrated by comparison with other coupling