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Triplex Formation Involving 2′-O,4′-C-Methylene Bridged Nucleic Acid (2′,4′-BNA) with 2-Pyridone Base Analogue: Efficient and Selective Recognition of C:G Interruption

✍ Scribed by Hidetaka Torigoe; Yoshiyuki Hari; Satoshi Obika; Takeshi Imanishi

Publisher: John Wiley and Sons
Year: 2004
Weight: 59 KB
Volume: 35
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200406193

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## Abstract Due to the instability of pyrimidine motif triplex DNA at physiological pH, triplex stabilization at physiological pH is crucial in improving its potential in various triplex‐formation‐based strategies in vivo, such as gene expression regulation, genomic DNA mapping, and gene‐targeted m