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ChemInform Abstract: Triplex-Forming Enhancement with High Sequence Selectivity by Single 2′-O,4′-C-Methylene Bridged Nucleic Acid (2′,4′-BNA) Modification.

✍ Scribed by Satoshi Obika; Yoshiyuki Hari; Tomomi Sugimoto; Mitsuaki Sekiguchi; Takeshi Imanishi

Publisher: John Wiley and Sons
Year: 2001
Weight: 27 KB
Volume: 32
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200108215

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## Abstract Due to the instability of pyrimidine motif triplex DNA at physiological pH, triplex stabilization at physiological pH is crucial in improving its potential in various triplex‐formation‐based strategies in vivo, such as gene expression regulation, genomic DNA mapping, and gene‐targeted m