✦ LIBER ✦

Triphosgene as highly efficient reagent for the solid-phase coupling of N-alkylated amino acids—total synthesis of cyclosporin O

✍ Scribed by Bernd Thern; Joachim Rudolph; Günther Jung

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 217 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00657-3

No coin nor oath required. For personal study only.

✦ Synopsis

A novel, highly efficient and racemization free coupling procedure for sterically hindered N-alkyl amino acids has been developed using triphosgene and a combination of diisopropylethyl amine (DIEA) and collidine at room temperature. Its efficiency was demonstrated by comparison with other coupling methods for N-alkylated amino acids and by solid-phase synthesis of the immunosuppressant cyclosporin O which was obtained in excellent purity and yield.

📜 SIMILAR VOLUMES

Efficient, Racemization-Free Peptide Cou

Efficient, Racemization-Free Peptide Coupling of N-Alkyl Amino Acids by Using Amino Acid Chlorides Generated in situ — Total Syntheses of the Cyclopeptides Cyclosporin O and Omphalotin A.

✍ Norbert Sewald 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 52 KB 👁 2 views

Efficient, Racemization-Free Peptide Cou

Efficient, Racemization-Free Peptide Coupling of N-Alkyl Amino Acids by Using Amino Acid Chlorides Generated In Situ—Total Syntheses of the Cyclopeptides Cyclosporin O and Omphalotin A

✍ Norbert Sewald 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB 👁 2 views

ChemInform Abstract: DCC—Celite Hybrid I

ChemInform Abstract: DCC—Celite Hybrid Immobilized Solid Support as a New, Highly Efficient Reagent for the Synthesis of O-Alkyl Hydrogen Alkylphosphonates under Solvent-Free Conditions.

✍ A. K. Gupta; Rajesh Kumar; H. K. Gupta; Vijay Tak; D. K. Dubey 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views