Highly effective and enantioselective α-amination of aldehydes promoted by chiral proline amide–thiourea bifunctional catalysts
✍ Scribed by Ji-Ya Fu; Qing-Chun Huang; Qiao-Wei Wang; Li-Xin Wang; Xiao-Ying Xu
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 359 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
A series of secondary amine-thiourea catalysts derived from L-proline and chiral diamine were prepared and first applied to the Michael addition of a,a-disubstituted aldehydes to trans-b-nitroalkenes. Moderate yields (47-75%) and excellent enantioselectivities (up to 96% ee) were obtained for a vari
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