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Highly asymmetric Michael additions of α,α-disubstituted aldehydes to β-nitroalkenes promoted by chiral pyrrolidine–thiourea bifunctional catalysts

✍ Scribed by Jian-Fei Bai; Xiao-Ying Xu; Qing-Chun Huang; Lin Peng; Li-Xin Wang

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
364 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

A series of secondary amine-thiourea catalysts derived from L-proline and chiral diamine were prepared and first applied to the Michael addition of a,a-disubstituted aldehydes to trans-b-nitroalkenes. Moderate yields (47-75%) and excellent enantioselectivities (up to 96% ee) were obtained for a variety of aryl and heteroaryl nitroalkenes.

📜 SIMILAR VOLUMES

A Chiral Primary Amine Thiourea Catalyst
A Chiral Primary Amine Thiourea Catalyst for the Highly Enantioselective Direct Conjugate Addition of α,α-Disubstituted Aldehydes to Nitroalkenes.
✍ Mathieu P. Lalonde; Yonggang Chen; Eric N. Jacobsen 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 44 KB 👁 2 views

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