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Highly effective and enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones promoted by simple chiral primary amine thiourea bifunctional catalysts

✍ Scribed by Ren-Qiang Mei; Xiao-Ying Xu; Yan-Chun Li; Ji-Ya Fu; Qing-Chun Huang; Li-Xin Wang


Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
227 KB
Volume
52
Category
Article
ISSN
0040-4039

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Highly asymmetric Michael additions of α
✍ Jian-Fei Bai; Xiao-Ying Xu; Qing-Chun Huang; Lin Peng; Li-Xin Wang 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 364 KB

A series of secondary amine-thiourea catalysts derived from L-proline and chiral diamine were prepared and first applied to the Michael addition of a,a-disubstituted aldehydes to trans-b-nitroalkenes. Moderate yields (47-75%) and excellent enantioselectivities (up to 96% ee) were obtained for a vari