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Highly Diastereoselective Synthesis of Nucleoside Adducts from the Carcinogenic Benzo[ a ]pyrene Diol Epoxide and a Computational Analysis

✍ Scribed by Lakshman, Mahesh K.; Keeler, John C.; Ngassa, Felix N.; Hilmer, John H.; Pradhan, Padmanava; Zajc, Barbara; Thomasson, Kathryn A.

Book ID
126924365
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
582 KB
Volume
129
Category
Article
ISSN
0002-7863

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In vivo formation of benzo (a) pyrene di
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## Abstract The hydrocarbon‐deoxyribonucleoside adducts formed in mouse skin DNA have been determined following topical application of an initiating dose of benzo(a)pyrene to Swiss mice, a strain shown to be susceptible to benzo(a)pyrene‐induced skin carcinogenesis. Several DNA‐bound products were