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Benzo[a]pyrene diol-epoxide DNA adducts and levels of polycyclic aromatic hydrocarbons in autoptic samples from human lungs

✍ Scribed by Maura Lodovici; Victor Akpan; Luca Giovannini; Francesca Migliani; Piero Dolara


Book ID
114009660
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
156 KB
Volume
116
Category
Article
ISSN
0009-2797

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DNA adducts are mainly detected by 32 P-postlabeling and enzyme-linked immunosorbent assays. We have established a method for detection of benzo[a]pyrene-diol-epoxide (BPDE)-DNA adducts by flow cytometry, and have clarified the effects of the DNA adducts on cell-cycle progression and the relationshi