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The melanocortin peptides that include the ฮฑ-, ฮฒ-, ฮณ-melanocyte stimulating hormones (MSH) and adrenocorticotrophin (ACTH) all possess a His-Phe-Arg-Trp epitope that is known as the 'message' sequence. These peptides are responsible for a range of physiological actions including skin pigmentation, e
## Estrogen receptor ligands Novel estrogens having tissue selective action suitable for menopausal hormone replacement or the treatment and prevention of breast cancer are current targets of interest. A solid phase parallel approach has been used to discover small molecule estrogen receptor ligand
Autophagy, a tightly regulated homeostatic pro-survival mechanism, has also been implicated in pathogen recognition and clearance by macrophages as part of the innate immune response. In the May issue of EJI, Mitroulis et al. shed light into the role of autophagy in human neutrophil biology, associa