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High yielding synthesis of heterocyclic β-substituted alanine derivatives

✍ Scribed by Paula M.T. Ferreira; Hernâni L.S. Maia; Luís S. Monteiro

Book ID
104261474
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
252 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Heterocyclic [3-substituted alanine derivatives such as [3-(pyrazol-l-yl) and 13-(l,2,4-triazol-l-yl)-alanine are synthesized in high yields by a Michael addition of heterocyclic nucleophiles to N,N-bis(tert-butyloxycarbonyl)dehydroalanine methyl ester, using mild reaction conditions and simple work-up procedures.

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