Synthesis of heterocyclic substituted norcantharidin derivatives
✍ Scribed by Liping Deng; Zhang Yong; Weifeng Tao; Jianfeng Shen; Wei Wang
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2011
- Tongue
- English
- Weight
- 116 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-152X
- DOI
- 10.1002/jhet.596
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✦ Synopsis
Abstract
Twenty novel norcantharidin derivatives, which were substituted by thiazole ring, were synthesized in a single step by the [3+2] 1,3‐dipolar cycloaddition reaction with oxime or hydrazone in the presence of chloramine‐T when compared with the conventional method. J. Heterocyclic Chem., (2011).
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## Abstract magnified image Highly efficient, practical and convenient synthesis of twelve compounds by the [3+2] 1, 3‐dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with two hydrazines in the presence of chloramine‐T. J. Heterocyclic Chem., (2009).
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## Abstract We use one molecule of ethylene diamine as a connecting arm to combine two molecules of 5,6‐dehydronorcantharidin. Then, ten novel norcantharidin derivatives were synthesized in a single step by the [3 + 2] 1,3‐dipolar cycloaddition reaction with oxime or hydrazone in the presence of ch