𝔖 Bobbio Scriptorium
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High yield selective 3′-silylation of ribonucleosides

✍ Scribed by Gholam H. Hakimelahi; Zbigniew A. Proba; Kelvin K. Ogilvie

Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
185 KB
Volume
22
Category
Article
ISSN
0040-4039

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✦ Synopsis

Procedures have been developed which permit the highly selective silylation of the 3'-hydroxyl of ribonucleosides to produce 3' ,5'-diprotected derivatives in high yields.

📜 SIMILAR VOLUMES

High yield protection of purine ribonucl
High yield protection of purine ribonucleosides for H-phosphonate RNA synthesis
✍ Xiaohu Zhang; José-Luis Abad; Qingtao Huang; Fan Zeng; Barbara L. Gaffney; Roger 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 188 KB

We report a new method for protecting nucleosides for hydrogen phosphonate RNA synthesis that gives very high yields for the purines. This method is based on our finding that, for adenosine and guanosine, silylation of a mixture of 2' and 3' H-phosphonates in the presence of DBU is highly selective