𝔖 Bobbio Scriptorium
✦   LIBER   ✦

High yield protection of purine ribonucleosides for H-phosphonate RNA synthesis

✍ Scribed by Xiaohu Zhang; José-Luis Abad; Qingtao Huang; Fan Zeng; Barbara L. Gaffney; Roger A. Jones

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
188 KB
Volume
38
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

We report a new method for protecting nucleosides for hydrogen phosphonate RNA synthesis that gives very high yields for the purines. This method is based on our finding that, for adenosine and guanosine, silylation of a mixture of 2' and 3' H-phosphonates in the presence of DBU is highly selective for the 2' hydroxyl.

📜 SIMILAR VOLUMES

An efficient preparation of protected ri
An efficient preparation of protected ribonucleosides for phosphoramidite RNA synthesis
✍ Vladimir Serebryany; Leonid Beigelman 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 111 KB

An efficient synthesis of protected ribonucleosides useful for phosphoramidite RNA synthesis is described. Di-t-butylsilylene group was employed for simultaneous protection of 3%-and 5%-hydroxyl functions of nucleoside. Subsequent silylation of free 2%-OH group followed by introduction of suitable p

ChemInform Abstract: Microwave-Assisted
ChemInform Abstract: Microwave-Assisted High Yielding Preparation of N-Protected 2′-Deoxyribonucleosides Useful for Oligonucleotide Synthesis.
✍ N. S. Rao; P. Kumar; V. K. Chauhan; B. S. Garg; K. C. Gupta 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v