High-Throughput Strategies for the Discovery of Catalysts
✍ Scribed by Ken D. Shimizu; Marc L. Snapper; Amir H. Hoveyda
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 123 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0947-6539
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✦ Synopsis
This paper provides a brief survey of the first attempts made to use principles of combinatorial chemistry and high-throughput strategies to identify effective organometallic chiral catalysts. The scope and limitations of each advance and its relevance to future investigations are discussed.
📜 SIMILAR VOLUMES
About 1000 catalytic or stoichiometric asymmetric reactions of racemic compounds or prochiral substrates bearing enantiotopic groups can be analyzed per day. In this highly efficient method the enantioselectivity is determined by electrospray ionization mass spectrometry using isotopically labeled s