An automated sample preparation for high throughput accurate mass determinations by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has been developed. Sample preparation was performed with an automated workstation and automated mass analyses were performed
High-throughput DNA analysis by time-of-flight mass spectrometry
β Scribed by Monforte, Joseph A.; Becker, Christopher H.
- Book ID
- 109927713
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 451 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1078-8956
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## Abstract Matrixβassisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) timeβofβflight mass spectrometry (TOFMS) play an essential role in the analysis of biological molecules, not only peptides and proteins, but also DNA and RNA. Tandem mass spectrometry used for sequence
This work presents a simple method for obtaining homogeneous sample surfaces in matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOFMS) for the automated analysis of peptides and proteins. The sample preparation method is based on applying the sample/matrix mixture