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High Susceptibility to Cerebral Ischemia in GFAP-Null Mice

✍ Scribed by Nawashiro, Hiroshi; Brenner, Michael; Fukui, Shinji; Shima, Katsuji; Hallenbeck, John M.


Book ID
110079096
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
623 KB
Volume
20
Category
Article
ISSN
0271-678X

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## Abstract We have demonstrated previously that the protein tyrosine phosphatase SHP‐1 seems to play a role in glial development and is upregulated in non‐dividing astrocytes after injury. The present study examines the effect of loss of SHP‐1 on the CNS response to permanent focal ischemia. SHP‐1