High specific activity tritium labelling of some sigma-1 receptor agonists
β Scribed by David G. Ahern; Richard J. Seguin; Crist N. Filer
- Book ID
- 113073168
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 267 KB
- Volume
- 292
- Category
- Article
- ISSN
- 1588-2780
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The tobacco smoke p a r t i c u l a t e phase marker d o t r i a c o n t a n e was l a b e l l e d w i t h tritium a t p o s i t i o n s 15, 16, 1 7 and 18 by t h e c a t a l y t i c r e d u c t i o n of dotriaconta-15, 17-diyne. This was obtained by o x i d a t i v e l y coupling hexadec-1-yne, i n
## Abstract Activated palladium is used as catalyst for the hydrogenβtritium exchange in tricyclic antidepressants. The specific activities obtained are: desipramine: 44.9 Ci/mmol; imipramine: 14.9 Ci/mmol; notriptyline: 2.0 Ci/mmol and amitriptyline: 1.7 Ci/mmol.
Since its introduction to medicine several years ago, diphenylhydantoin (DPH) has been widely used in the treatment of epilespy, both in adults and children.( 2) The effects of the drug is well correlated with the plasma levels. high levels have adverse effects. ( 3 )