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High specific activity tritiated prostaglandin analogs I: Synthesis of enprostil-[13, 14-3H]

✍ Scribed by Howard Parnes

Book ID
102901124
Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
542 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Partial reduction of the acetylenic precursor 1 with carrier‐free tritium gas in the presence of Lindlar catalyst gave the highly labelled cis‐allylic alcohol 2. Tritium was thus contained in the metabolically stable 13,14‐position of the lower side chain. Elaboration of 2 via a fourteen step, microscale sequence gave enprostil‐[13,14‐^3^H] 19 having a specific activity of 41 Ci/mmol.

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