High-resolution ultra-high mass spectrometry: Increasing the m/z range of protein analysis
β Scribed by Huijuan Chen; Jeonghoon Lee; Peter T. A. Reilly
- Book ID
- 115561034
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 778 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1615-9853
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A "micro-electrospray" ionization source has been developed that markedly increases the sensitivity of the conventional electrospray source. This was achieved by optimization of the source to accommodate nanoliter flow rates from 300 to 800-nL/min spraying directly from a capillary needle that, for
## Abstract Electrospray ionization (ESI) mass spectra have been measured on a magneticβsector doubleβfocusing mass spectrometer for a number of proteins and peptides. It is pointed out how in theory raising the mass resolution of a mass spectrometer from 800β1000 to 2400β3000 significantly increas