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High-Resolution Melting Analyses for Gene Scanning of APC , MLH1 , MSH2 , and MSH6 Associated with Hereditary Colorectal Cancer

✍ Scribed by Obul, Jurat; Itoga, Sakae; Abliz, Maynur; Sato, Kenichi; Ishige, Takayuki; Utsuno, Emi; Matsushita, Kazuyuki; Matsubara, Hisahiro; Nomura, Fumio


Book ID
120505876
Publisher
Mary Ann Liebert
Year
2012
Tongue
English
Weight
643 KB
Volume
16
Category
Article
ISSN
1945-0265

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## Abstract A systematic search by Southern blot analysis in a cohort of 439 hereditary nonpolyposis colorectal cancer (HNPCC) families for genomic rearrangements in the main mismatch repair (MMR) genes, namely, __MSH2__, __MLH1__, __MSH6__, and __PMS2__, identified 48 genomic rearrangements causat