High-resolution structures of scytalone
✍
Zdzislaw Wawrzak; Tatyana Sandalova; James J. Steffens; Gregory S. Basarab; Toma
📂
Article
📅
1999
🏛
John Wiley and Sons
🌐
English
⚖ 522 KB
Scytalone dehydratase is a molecular target of inhibitor design efforts aimed at preventing the fungal disease caused by Magnaporthe grisea. A method for cocrystallization of enzyme with inhibitors at neutral pH has produced several crystal structures of enzyme-inhibitor complexes at resolutions ran