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High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors

✍ Scribed by Fradera, Xavier ;Kazemier, Bert ;Carswell, Emma ;Cooke, Andrew ;Oubrie, Arthur ;Hamilton, William ;Dempster, Maureen ;Krapp, Stephan ;Nagel, Susanna ;Jestel, Anja


Book ID
114529378
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
825 KB
Volume
68
Category
Article
ISSN
1744-3091

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High resolution crystal structures of tr
✍ Rajaram Venkatesan; Markus Alahuhta; Petri M. Pihko; Rik K. Wierenga πŸ“‚ Article πŸ“… 2011 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 720 KB

## Abstract The key residue of the active site of triosephosphate isomerase (TIM) is the catalytic glutamate, which is proposed to be important (i) as a catalytic base, for initiating the reaction, as well as (ii) for the subsequent proton shuttling steps. The structural properties of this glutamat