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Aconitase mechanism from crystal structures of the enzyme complexed to substrates and inhibitors.

✍ Scribed by H. Lauble; M.C. Kennedy; H. Beinert; C.D. Stout


Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
84 KB
Volume
51
Category
Article
ISSN
0162-0134

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Four substrate analogs-nicotinamide adenine dinucleotide, adenylyl (3, 5) guanosine, guanylyl (3,5) adenosine, and adenosine 2,5-diphosphate-have been used to prepare the complexes with trichosanthin (TCS), a type I ribosome-inactivating protein that possesses the activity of N-glycosidase. The crys