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High pressure activation in the asymmetric Michael addition of chiral imines to alkyl and aryl crotonates

✍ Scribed by Cheikhou Camara; Delphine Joseph; Françoise Dumas; Jean d'Angelo; Angèle Chiaroni

Book ID: 104250481
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 116 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00054-0

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✦ Synopsis

High pressure-mediated Michael addition of chiral imines derived from 2-methylcyclopentanone, 2-methylcyclohexanone and optically active 1-phenylethylamine, to methyl and phenyl crotonates was investigated. The corresponding adducts were obtained in fair yields and with a high degree of regio-, diastereo-and enantioselectivity.

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