o-Phthalaldehyde in combination with N-acetyl-L-cysteine is a useful derivatization reagent for the optical resolution of enantiomeric a-H-a-amino acids, a-alkyl-a-amino acids and the corresponding acid amides. By using reversed-phase high-performance liquid chromatography with a mobile phase contai
High-performance liquid chromatographic resolution of (R, S)-α-alkyl-α-amino acids as diastereomeric derivatives
✍ Scribed by H. Brückner; S. Zivny
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 700 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0939-4451
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
For studies on the coenzyme B,,-dependent enzyme, leucine-2,3-aminomutase, (3R)-and (3S)-&leucines were synthesized. The 1 0-camphorsulfonamide pnitrobenzyl esters could be resolved by normal-phase HPLC. A much better separation was obtained by reversed-phase HPLC of the diastereomeric derivatives o
## Abstract The liquid chromatographic enantiomer separation of __N__‐fluorenylmethoxycarbonyl (FMOC) protected α‐amino acids and their ethyl ester derivatives was performed on polysaccharide‐derived chiral stationary phases, Chiralcel OD, Chiralpak AD, and Chiralpak AS. In general, Chiralcel OD an