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High-performance liquid chromatographic method for the determination of sorafenib in human serum and peritoneal fluid

✍ Scribed by Werner J. Heinz; Kathrin Kahle; Annegret Helle-Beyersdorf; Diana Schirmer; Ulrike Lenker; Daniela Keller; Peter Langmann; Hartwig Klinker

Book ID
105993589
Publisher
Springer
Year
2010
Tongue
English
Weight
382 KB
Volume
68
Category
Article
ISSN
0344-5704

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High performance liquid chromatographic
High performance liquid chromatographic method for determination of canrenone in serum
✍ Besenfelder, E. ;Endele, R. πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 215 KB πŸ‘ 2 views

Spironolactone (I), a potassium sparing diuretic, is widely used in the treatment of edema. Metabolic degradation starts with rapid deacetylation, leading to the short lived a-thiol [l]. Subsequent elimination of hydrogen sulfide yields canrenone (II), which exists in enzymatic equilibrium with canr