High performance liquid chromatographic
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Besenfelder, E. ;Endele, R.
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Article
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1981
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John Wiley and Sons
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English
โ 215 KB
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Spironolactone (I), a potassium sparing diuretic, is widely used in the treatment of edema. Metabolic degradation starts with rapid deacetylation, leading to the short lived a-thiol [l]. Subsequent elimination of hydrogen sulfide yields canrenone (II), which exists in enzymatic equilibrium with canr