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High-performance liquid chromatographic determination of mepixanthone in serum

✍ Scribed by Gabriele Grossi; Avelia Lippi; Rita Battistoni; Elena Martelli; Carlo Sturani


Book ID
107996431
Publisher
Elsevier Science
Year
1984
Weight
278 KB
Volume
309
Category
Article
ISSN
0378-4347

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High performance liquid chromatographic
✍ Besenfelder, E. ;Endele, R. πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 215 KB πŸ‘ 2 views

Spironolactone (I), a potassium sparing diuretic, is widely used in the treatment of edema. Metabolic degradation starts with rapid deacetylation, leading to the short lived a-thiol [l]. Subsequent elimination of hydrogen sulfide yields canrenone (II), which exists in enzymatic equilibrium with canr