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High-performance liquid chromatographic analysis of the lactone and carboxylate forms of a topoisomerase I inhibitor (the antitumor drug GI147211) in plasma

โœ Scribed by C.G. Stafford; R.L. St. Claire III


Publisher
Elsevier Science
Year
1995
Weight
465 KB
Volume
663
Category
Article
ISSN
0378-4347

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High-performance liquid chromatographic
โœ J.H. Beijnen; B.R. Smith; W.J. Keijer; R. Van Gijn; W.W. Ten Bokkel Huinink; L.T ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 521 KB

A high-performance liquid chromatographic (HPLC) assay is described for the determination of the new, investigational antitumour drug SK&F 104864-A and its lactone ring opened form (SK&F 105992). The analytical methodology reported here involves a protein precipitation step with methanol as sample p