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Analysis of the active lactone form of 9-aminocamptothecin in plasma using solid-phase extraction and high-performance liquid chromatography

✍ Scribed by Chris H. Takimoto; Raymond W. Klecker; William L. Dahut; Lorrin K. Yee; John M. Strong; Carmen J. Allegra; Jean L. Grem


Publisher
Elsevier Science
Year
1994
Weight
487 KB
Volume
655
Category
Article
ISSN
0378-4347

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A method for the determination of lorazepam in rat brain is described using liquidhiquid and solid-phase extraction, followed by high performance liquid chromatography. After addition of chlordiazepoxide as the internal standard, 100 mg brain tissue was homogenized and incubated with alkaline protea