High Mobility Group Box 1: a potential therapeutic target for systemic lupus erythematosus
β Scribed by Hai-Feng Pan; Guo-Cui Wu; Wei-Ping Li; Xiang-Pei Li; Dong-Qing Ye
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 173 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0301-4851
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## Abstract High mobility group boxβ1 (HMGBβ1) is a nuclear protein that can bind to and condense plasmid DNA. In this study, we developed a recombinant VEGF receptor binding peptide (VRBP) linked to HMGBβ1 box A (VRBPβHMGB1A) as a targeting gene carrier to hypoxic endothelial cells. Hypoxic endoth
## Abstract ## Objective To investigate the role of the novel cytokine high mobility group box chromosomal protein 1 (HMGBβ1) in the pathogenesis of cutaneous lupus erythematosus (CLE). ## Methods Punch biopsy specimens of lesional and unaffected skin from 10 patients with CLE and 3 healthy cont