✦ LIBER ✦

High incidence of 17p13 chromosomal abnormalities in malignant histiocytosis

✍ Scribed by Rokuo Abe; Yasushi Akaike; Akiko Yokoyama; Yayoi Shikama; Toshiyuki Ishibashi; Masayuki Mita; Hideo Kimura; Tatsumi Uchida; Shigeo Kariyone; Haruki Wakasa

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 743 KB
Volume: 65
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19900615)65:12<2689::aid-cncr2820651216>3.0.co;2-1

No coin nor oath required. For personal study only.

✦ Synopsis

Cytogenetic analyses of three patients during autopsy who had a pathologic diagnosis of malignant histiocytosis and of one patient who was strongly suspected to have malignant histiocytosis because of her clinical and hematologic findings were done. All three patients studied with bone marrow specimens showed polyploidy (3.4-20%). Two of three patients with chromosomal abnormalities showed 17p' markers with a breakpoint at 17~13. Seven of 22 previously reported malignant histiocytosis patients (32%) with descriptions of detailed whole karyotypes have the 17p' markers, including two of the authors' patients. Five of seven patients with 17p+ involved 17~13. Although breakpoints at the 17p' in the remaining two were not described, their karyotypes were shown to possibly involve 17~13. The high incidence of this abnormality is not considered accidental, and this breakpoint is not usual in many other neoplastic disorders. These facts may indicate that 1 7 ~1 3 chromosome abnormality is a specific change of malignant histiocytosis. Cancer 652689-2696,1990.

ALIGNANT HISTIOCYTOSIS (MH) iS a rare hema-

📜 SIMILAR VOLUMES

Dysplastic cells in cytological cervical

Dysplastic cells in cytological cervical samples show a high incidence of chromosomal abnormalities

✍ Minghao Song; Adam Ruth; Frank A. Policht; Lukas Bubendorf; Georg Feichter; Benj 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 135 KB

A T-cell neoplasia showing clinicopathol

A T-cell neoplasia showing clinicopathologic features of malignant histiocytosis with novel chromosomal abnormalities and N-ras mutation

✍ Takahiro Itoyama; Naoki Sadamoriy; Ippei Sasagawa; Hideo Nakamura; Seiji Tokunag 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 930 KB

Malignant histiocytosis (MH) is a distinct disease entity defined clinically and morphologically. However, the neoplastic origin of MH is not well established. The authors report a 26-year-old woman who showed the typical clinicopathologic features of so-called MH. Cytogenetic and molecular genetic

Malignant astrocytoma-derived region of

Malignant astrocytoma-derived region of common amplification in chromosomal band 17p12 is frequently amplified in high-grade osteosarcomas

✍ Theo J. M. Hulsebos; Engelien H. Bijleveld; Niels T. Oskam; Andries Westerveld; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 107 KB

Recently, we reported a new amplification event that involves marker D17S67 in 17p12 in three malignant astrocytomas of patients with a very short survival. The amplified region may contain an oncogene implicated in astrocytoma tumorigenesis. To determine the extent of the amplified regions, we cons

Trisomy 2, trisomy 20, and del(17p) as s

Trisomy 2, trisomy 20, and del(17p) as sole chromosomal abnormalities in three cases of hepatoblastoma

✍ Vijay S. Tonk; Kathleen S. Wilson; Charles F. Timmons; Nancy R. Schneider 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 693 KB

## Short -term cultures of three hepatoblastomas were analyzed cytogenetically. Trisomy 2, trisomy 20, and a deletion of I7p were found as the sole abnormalities, yielding the karyotypes 47,XY, + 2 47,XX, + 20; and 46,XX,del( I7)(p I2)/46,XX. This is the first reported case of deletion of 17p as t

Sequence-Based, in situ detection of chr

Sequence-Based, in situ detection of chromosomal abnormalities at high resolution

✍ Knoll, Joan H.M. ;Rogan, Peter K. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 253 KB 👁 2 views

## Abstract We developed single copy probes from the draft genome sequence for fluorescence in situ hybridization (scFISH) which precisely delineate chromosome abnormalities at a resolution equivalent to genomic Southern analysis. This study illustrates how scFISH probes detect cryptic and subtle a

High frequency of allelic deletion on ch

High frequency of allelic deletion on chromosome 17p in advanced colorectal cancer

✍ Kyaw Khine; Duncan R. Smith; Hak-Su Goh 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 962 KB

Background. Colorectal cancers often show allelic loss of chromosomes 5q and 17p, regions where the tumor suppressor genes p53 and adenomatous polyposis coli are known to reside. Currently, the inactivation of tumor suppressor genes and the activation of oncogenes are considered major events involve