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High glucose-induced apoptosis through store-operated calcium entry and calcineurin in human umbilical vein endothelial cells

✍ Scribed by Sophie Tamareille; Olivier Mignen; Thierry Capiod; Catherine Rücker-Martin; Danielle Feuvray

Book ID
113525538
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
425 KB
Volume
39
Category
Article
ISSN
0143-4160

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## Abstract Hyperglycemia and elevation of methylglyoxal (MG) are symptoms of diabetes mellitus (DM). We previously showed that high glucose (HG; 30 mM) or MG (50–400 µM) could induce apoptosis in mammalian cells, but these doses are higher than the physiological concentrations of glucose and MG in