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High efficiency adenovirus-mediated pericardial gene transfer in vivo

✍ Scribed by Michael Woody; Khawar Mehdi; Douglas P. Zipes; Mark Brantley; Bruce L. Trapnell; Keith L. March

Book ID
118584815
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
163 KB
Volume
27
Category
Article
ISSN
1558-3597

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We used recombinant adenoviruses as a means of expressing exogenous genes in olfactory neurons in vivo. A replication incompetent adenovirus (type 5, Ad5) carrying the reporter gene lacZ, which codes for the enzyme 8-galactosidase (,&Gal), was applied in solution to the olfactory epithelia of rats.