Transfer of therapeutic genes into muscle tissue has promise for the treatment of a variety of muscular dystrophies. Various vectors have been used to deliver genes to skeletal muscle but their application has faced several major limitations including: (1) the lack of transgene persistence caused by
✦ LIBER ✦
Ovine adenovirus vectors mediate efficient gene transfer to skeletal muscle
✍ Scribed by Löser, P; Hillgenberg, M; Arnold, W; Both, G W; Hofmann, C
- Book ID
- 110038749
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 520 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0969-7128
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## Abstract ## Background Recombinant adenoviruses (rAd) are well‐characterized viral vectors and have been studied in many human diseases. However, there are no detailed methods for transferring genes to the stomach using rAd. ## Methods Gastric epithelial cells were infected with rAd encoding