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Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice

✍ Scribed by Ragot, Thierry; Vincent, Nathalie; Chafey, Philippe; Vigne, Emmanuelle; Gilgenkrantz, Hélène; Coutont, Dominque; Cartaud, Jean; Briand, Pascale; Kaplant, Jean-Claude; Perricaude, Michel


Book ID
109783296
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
628 KB
Volume
361
Category
Article
ISSN
0028-0836

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## Abstract ## Background The helper‐dependent adenovirus (HDAd) vector is less immunogenic and has a larger cloning capacity of up to 37 kb enough to carry the full‐length dystrophin cDNA. However, high and long‐term expression of dystrophin transduced to mature muscle still remains difficult. On