𝔖 Bobbio Scriptorium
✦   LIBER   ✦

High dose systemic methotrexate-associated acute neurologic dysfunction

✍ Scribed by Packer, Roger J. ;Grossman, Robert I. ;Belasco, Jean Bello

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
319 KB
Volume
11
Category
Article
ISSN
0098-1532

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✦ Synopsis

Two patients treated with high dose methof symptoms. Computed tomography in one otrexate with citrovorum rescue (HDMTX-CF) child disclosed a large low absorption abnorfor osteogenic sarcoma developed the acute mality. This patient represents the first reonset of neurologic deficits. Prior to the onset ported case of positive radiologic findings of symptoms, one child suffered brief epi-associated with this syndrome. The two pasodes of altered consciousness. Both patients tients recovered completely and received furdeveloped hemiparesis and then steadily im-ther HDMTX-CF without sequelae. This proved over 72 hours. Laboratory evaluations condition may result from transient demyelidisclosed normal coagulation parameters and nation or embolic cerebrovascular disease. nontoxic serum methotrexate levels at onset

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