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High dose methotrexate as a preoperative adjuvant in the treatment of epidermoid carcinoma of the head and neck: A feasibility study and clinical trial

โœ Scribed by John L. Tarpley; Paul B. Chretien; John C. Alexander Jr; Robert C. Hoye; Jerome B. Block; Alfred S. Ketcham

Book ID
115691741
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
575 KB
Volume
130
Category
Article
ISSN
0002-9610

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## Abstract Eleven patients with squamous carcinoma of the head and neck who were scheduled for surgical resection or endoscopic biopsy of tumor received 15 mg/m^2^ of methotrexate (MTX). Samples of tumor, normal mucosa, and plasma were obtained at surgery or endoscopy, 18โ€24 hours after the last M