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High affinity dopamine D2 receptor radioligands. 2. [125I]epidepride, a potent and specific radioligand for the characterization of striatal and extrastriatal dopamine D2 receptors

✍ Scribed by Robert M. Kessler; M. Sib Ansari; Dennis E. Schmidt; Tomas de Paulis; Jeffrey A. Clanton; Roberts Innis; Mohammed Al-Tikriti; Ronald G. Manning; David Gillespie

Book ID
118344855
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
995 KB
Volume
49
Category
Article
ISSN
0024-3205

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πŸ“œ SIMILAR VOLUMES

Preparation of [123I]- and [125I]epidepr
Preparation of [123I]- and [125I]epidepride: A dopamine D-2 receptor antagonist radioligand
✍ J. A. Clanton; T. de Paulis; D. E. Schmidt; M. S. Ansari; R. G. Manning; R. M. B πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 French βš– 412 KB

## Abstract (__S__)‐(βˆ’)‐__N__‐[(1‐ethyl‐2‐pyrrolidinyl)methyl]‐5‐[^123^I]iodo‐2,3‐dimethoxybenzamide (TDP 517) (proposed generic name, [^123^I]epidepride) is the iodine‐123 substituted analogue of isoremoxipride (FLB 457), both of which are very potent dopamine D‐2 antagonists (epidepride K~D~ 0.02

Kinetic and equilibrium analyses of [123
Kinetic and equilibrium analyses of [123I]epidepride binding to striatal and extrastriatal dopamine D2 receptors
✍ Masahiro Fujita; John P. Seibyl; N. Paul L.G. Verhoeff; Masanori Ichise; Ronald πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 327 KB

Quantitative SPECT measures of dopamine D 2 like receptors with [ 123 I]epidepride is complicated by its high affinity and lipophilic metabolites. The purpose of this study was to use both parent (P) and lipophilic metabolites (M) as input functions in a kinetic paradigm and in comparison to the res