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Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2receptors using [123I]epidepride SPET

✍ Scribed by Masahiro Fujita; Andrea Varrone; KyeongMin Kim; Hiroshi Watabe; SamiS. Zoghbi; Nicholas Seneca; Dnyanesh Tipre; JohnP. Seibyl; RobertB. Innis; Hidehiro Iida

Publisher: Springer
Year: 2004
Tongue: English
Weight: 454 KB
Volume: 31
Category: Article
ISSN: 0340-6997
DOI: 10.1007/s00259-003-1431-7

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Quantitative SPECT measures of dopamine D 2 like receptors with [ 123 I]epidepride is complicated by its high affinity and lipophilic metabolites. The purpose of this study was to use both parent (P) and lipophilic metabolites (M) as input functions in a kinetic paradigm and in comparison to the res