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HIF–prolyl hydroxylases and cardiovascular diseases

✍ Scribed by Sen Banerjee, Sucharita; Thirunavukkarasu, Mahesh; Rishi, Muhammad Tipu; Sanchez, Juan A.; Maulik, Nilanjana; Maulik, Gautam

Book ID
118170196
Publisher
Taylor and Francis Group
Year
2012
Tongue
English
Weight
854 KB
Volume
22
Category
Article
ISSN
1051-7235

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## Abstract Hypoxia and induction of hypoxia‐inducible factors (HIF‐1α and HIF‐2α) is a hallmark of many tumors. Under normal oxygen tension HIF‐alpha subunits are rapidly degraded through prolyl hydroxylase dependent interaction with the von Hippel‐Lindau (VHL) tumor suppressor protein, a componen