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HIF-1 and tumor progression: pathophysiology and therapeutics

โœ Scribed by Gregg L. Semenza


Book ID
118626455
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
316 KB
Volume
8
Category
Article
ISSN
1471-4914

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HIF-1 and tumor progression: pathophysio
โœ Gregg L. Semenza ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 316 KB

Hypoxia-inducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) and metabolic adaptation to hypoxia (via glycolysis). HIF-1 consists of a constitutively expressed HIF-1ฮฒ subunit and an oxygen-and growth-factor-regulated HIF-1ฮฑ subunit. In xenografts, tumor growth and angiogenesis are