HIF-1 and tumor progression: pathophysio
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Gregg L. Semenza
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Article
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2002
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Elsevier Science
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English
โ 316 KB
Hypoxia-inducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) and metabolic adaptation to hypoxia (via glycolysis). HIF-1 consists of a constitutively expressed HIF-1ฮฒ subunit and an oxygen-and growth-factor-regulated HIF-1ฮฑ subunit. In xenografts, tumor growth and angiogenesis are