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HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

✍ Scribed by Keith, Brian; Johnson, Randall S.; Simon, M. Celeste

Book ID
109948857
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
531 KB
Volume
12
Category
Article
ISSN
1474-1776

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## Abstract Hypoxia‐inducible factor (HIF)‐1 and HIF‐2 are heterodimeric transcription factors that mediate the cellular response to hypoxia. Their key regulatory subunits, HIF‐1α and HIF‐2α, are induced similarly by hypoxia, but their functional roles in cancer may be distinct and isoform‐specific