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Hexafluoroacetone as a Protecting and Activating Reagent. Regioselective Esterification of Aspartic, Malic, and Thiomalic Acid

✍ Scribed by Ksenia Pumpor; Elisabeth Windeisen; Jan Spengler; Fernando Albericio; Klaus Burger


Book ID
106213412
Publisher
Springer Vienna
Year
2004
Tongue
English
Weight
323 KB
Volume
135
Category
Article
ISSN
0026-9247

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Synthesis of heteroaryl substituted Ξ±-me
✍ Ksenia Pumpor; Elisabeth Windeisen; Klaus Burger πŸ“‚ Article πŸ“… 2003 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 99 KB πŸ‘ 1 views

## Abstract The synthesis of heterocyclic α‐mercapto acids starting from (__RS__)‐thiomalic acid using hexafluoroacetone as protecting and activating agent is described. The new compounds are useful building blocks for peptide and depsipeptide modification as well as for drug design.