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Hexachlorocyclohexane-induced behavioural and neurochemical changes in rat

✍ Scribed by Arjun Sahoo; Luna Samanta; Alaka Das; Sarat K. Patra; Gagan B. N. Chainy

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 90 KB
Volume: 19
Category: Article
ISSN: 0260-437X
DOI: 10.1002/(sici)1099-1263(199901/02)19:1<13::aid-jat531>3.0.co;2-e

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✦ Synopsis

Effect of chronic oral exposure (10 and 20 mg kg -1 body wt. for 7, 15 and 30 days) to hexachlorocyclohexane (HCH) on open-field behaviour and activities of cerebral Na + ,K + -ATPase, Mg 2+ -ATPase and acetylcholinesterase (AChE) of rat was evaluated. Motor and grooming activities were altered, whereas vertical exploratory activity was unaffected by HCH. Activities of Na + ,K + -ATPase, Mg 2+ -ATPase and AChE were inhibited significantly by the pesticide. The results suggest that HCH induces impairment of the enzymes involved in synaptic activity, resulting in behavioural alterations.

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