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Heterozygosity for the CCR-5 Δ32 deletion, HIV-1 transmission and disease progression

✍ Scribed by Marinunzia Catucci; Giulietta Venturi; Laura Romano; Angelo De Milito; Maurizio Zazzi

Book ID: 111107689
Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 298 KB
Volume: 4
Category: Article
ISSN: 1198-743X
DOI: 10.1111/j.1469-0691.1998.tb00074.x

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## Abstract Homozygous (Δccr5/Δccr5) and heterozygous (CCR5/Δccr5) deletions in the β‐chemokine receptor 5 (CCR5) gene, which encodes for the major co‐receptor for macrophage‐tropic HIV‐1 entry, have been implicated in resistance to HIV infection and in protection against disease progression, respe