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Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia

✍ Scribed by Graux, C; Stevens-Kroef, M; Lafage, M; Dastugue, N; Harrison, C J; Mugneret, F; Bahloula, K; Struski, S; Grégoire, M J; Nadal, N

Book ID: 109886643
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 481 KB
Volume: 23
Category: Article
ISSN: 0887-6924
DOI: 10.1038/leu.2008.278

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## Abstract Gene amplification is a relatively rare event in hematologic malignancies. The __ABL__ gene on chromosome band 9q34 is a proto‐oncogene and is the well‐known translocation partner of the __BCR__ gene on 22q11 giving rise to t(9;22)(q34;q11), which is the hallmark of chronic myeloid leuk

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