Amplification of the ABL gene in T-cell acute lymphoblastic leukemia
β Scribed by Barber, K E; Martineau, M; Harewood, L; Stewart, M; Cameron, E; Strefford, J C; Rutherford, S; Allen, T D; Broadfield, Z J; Cheung, K L
- Book ID
- 110055883
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 127 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0887-6924
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Gene amplification is a relatively rare event in hematologic malignancies. The __ABL__ gene on chromosome band 9q34 is a protoβoncogene and is the wellβknown translocation partner of the __BCR__ gene on 22q11 giving rise to t(9;22)(q34;q11), which is the hallmark of chronic myeloid leuk
## Abstract Tβcell acute lymphoblastic leukemia (TβALL) is the result of multiple oncogenic insults of thymocytes. Recently, new __ABL1__ fusion genes have been identified that provide proliferation and survival advantage to lymphoblasts. These are the __NUP214βABL1__ fusion gene, on amplified epis