In acute leukemia (AL) with a late-appearing Philadelphia (la-Ph) translocation, it is unclear whether these translocations arise from the same molecular event as classical Ph translocations. In order to elucidate the molecular events of la-Ph and subsequent translocations of la-Ph leukemia, we perf
Molecular detection of a late-appearing BCR-ABL gene in a child with T-cell acute lymphoblastic leukemia
✍ Scribed by A. Tchirkov; J.-M. Bons; J. Chassagne; C. Schoepfer; J. Kanold; G. Briançon; M. Giollant; P. Malet; F. Deméocq
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 208 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0939-5555
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of a de novo Ph in T-cell acute leukemia. So this case could be the first de novo T-cell childhood ALL showing the expression of p210 protein associated with a very aggressive clinical evolution.
## Abstract Gene amplification is a relatively rare event in hematologic malignancies. The __ABL__ gene on chromosome band 9q34 is a proto‐oncogene and is the well‐known translocation partner of the __BCR__ gene on 22q11 giving rise to t(9;22)(q34;q11), which is the hallmark of chronic myeloid leuk